Methamphetamine Action Team Kern County PSA’s (English)
April 15, 2011 - 1:00 am
Posts Tagged ‘action’
Mode of action of trabedersen (AP12009) in Cancer Treatment
February 17, 2010 - 7:07 am
Malignant brain tumors (high-grade glioma), pancreatic cancer and malignant melanoma are among the most aggressive tumors known. Antisense Pharma is vigorously testing its product trabedersen (AP 12009) in different clinical studies with the aim to meet the unmet medical need for effective and innovative approaches to treat these cancers. Trabedersen downregulates the generation of one of the most important tumor-promoting factors – TGF-beta2 (TGF-β2) – at the molecular level. With its proangiogenic and promigratory effects, TGF-β2 plays a pivotal role in explosive tumor progression and the aggressive spread of tumor cells throughout the body (metastazation). In addition, tumor-derived TGF-β2 overexpression builds up a protective shield around the tumor. This shield results in an inactivation of immune cells and allows the tumor to escape the bodys immune surveillance. The tumor cells can spread unhindered throughout the body. The antisense drug trabedersen blocks the translation of the TGF-β2 mrna and thus downregulates its synthesis, destroying the protective shield around the tumor. Further tumor growth is consequently inhibited and the bodys own immune system is reactivated, enabling the immune cells to combat the cancer cells.
MOVIE teaser/thriller, action, horror, drama, suspense Sebastian Siegel
January 11, 2010 - 4:10 am
Sebastian Siegel film/Lost, Preys, Atheist, CSI, Cross, Void, Risk, thriller, action, horror, drama, suspense die kill burn … “Sebastian Siegel” Lost Preys guns arms speed drama athlete thriller action horror blood mystery fight Iron Man ironman die kill boxing shoot overdose punch power cross cigarette murder acting actor heat knives Jesus Judas kick knockout “los angeles” film movie “new york” cops nude dealer police news cocaine drugs smuggle movies sebastian scene crime criminal sex …
